NEK2 Antikörper (AA 1-135)

Produktnummer ABIN7169100

Der Kaninchen Polyklonal Anti-NEK2-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, NEK2 in Proben von Human zu detektieren.

Kurzübersicht für NEK2 Antikörper (AA 1-135) (ABIN7169100)

Target: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-NEK2 Antikörper

Bindungsspezifität: AA 1-135

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase Nek2 protein (1-135AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NEK2

Target: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Andere Bezeichnung: NEK2

Hintergrund:

Background: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC, SGOL1, NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.

Aliases: HSPK 21 antibody, HsPK21 antibody, NEK 2 antibody, NEK2 antibody, NEK2_HUMAN antibody, NEK2A antibody, Never in mitosis A-related kinase 2 antibody, NIMA (never in mitosis gene a) related kinase 2 antibody, NimA like protein kinase 1 antibody, NIMA related kinase 2 antibody, NimA related protein kinase 2 antibody, NimA-like protein kinase 1 antibody, NimA-related protein kinase 2 antibody, NLK 1 antibody, NLK1 antibody, Serine/threonine-protein kinase Nek2 antibody

UniProt: P51955

Pathways: M Phase