ATR Antikörper (AA 2405-2644) (HRP)

Produktnummer ABIN7169014

Dieses Anti-ATR-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATR in ELISA. Geeignet für Human.

Kurzübersicht für ATR Antikörper (AA 2405-2644) (HRP) (ABIN7169014)

Target: ATR (ATR serine/threonine kinase (ATR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATR Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-ATR Antikörper (HRP)

Bindungsspezifität: AA 2405-2644

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase ATR protein (2405-2644AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Andere Bezeichnung: ATR

Hintergrund:

Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates \\\'Ser-139\\\' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Aliases: Ataxia telangiectasia and Rad3 related antibody, Ataxia telangiectasia and Rad3-related protein antibody, ATR antibody, ATR_HUMAN antibody, FCTCS antibody, FRAP Related Protein 1 antibody, FRAP-related protein 1 antibody, FRP1 antibody, MEC1 antibody, MEC1 mitosis entry checkpoint 1 homolog antibody, Protein kinase ATR antibody, RAC3 antibody, Rad3 related protein antibody, SCKL antibody, SCKL1 antibody, Serine/threonine protein kinase ATR antibody, Serine/threonine-protein kinase ATR antibody

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus