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RIPK2 Antikörper (AA 1-540) (Biotin)

RIPK2 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN7167476
  • Target Alle RIPK2 Antikörper anzeigen
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    Bindungsspezifität
    • 12
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-540
    Reaktivität
    • 72
    • 39
    • 21
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 66
    • 7
    • 1
    Kaninchen
    Klonalität
    • 68
    • 6
    Polyklonal
    Konjugat
    • 45
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RIPK2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 58
    • 35
    • 27
    • 11
    • 10
    • 7
    • 5
    • 3
    • 2
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 protein (1-540AA)
    Isotyp
    IgG
    Top Product
    Discover our top product RIPK2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    Andere Bezeichnung
    RIPK2 (RIPK2 Produkte)
    Synonyme
    RIPK2 antikoerper, 2210420D18Rik antikoerper, CARD3 antikoerper, CARDIAK antikoerper, CCK antikoerper, D4Bwg0615e antikoerper, RICK antikoerper, RIP2 antikoerper, GIG30 antikoerper, receptor interacting serine/threonine kinase 2 antikoerper, receptor (TNFRSF)-interacting serine-threonine kinase 2 antikoerper, receptor-interacting serine-threonine kinase 2 antikoerper, RIPK2 antikoerper, Ripk2 antikoerper
    Hintergrund

    Background: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes \\\'Lys-63\\\'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces \\\'Lys-63\\\'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

    Aliases: CARD 3 antibody, CARD carrying kinase antibody, CARD containing ICE associated kinase antibody, CARD containing IL 1 beta ICE kinase antibody, CARD containing IL1 beta ICE kinase antibody, CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody, CARD containing interleukin 1 beta converting enzyme associated kinase antibody, CARD-containing IL-1 beta ICE-kinase antibody, CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody, CARD3 antibody, CARDIAK antibody, CCK antibody, CLARP kinase antibody, GIG 30 antibody, GIG30 antibody, Growth inhibiting gene 30 antibody, Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody, Receptor interacting protein 2 antibody, Receptor interacting serine threonine kinase 2 antibody, Receptor interacting serine/threonine protein kinase 2 antibody, Receptor-interacting protein 2 antibody, Receptor-interacting serine/threonine-protein kinase 2 antibody, RICK antibody, RIP 2 antibody, RIP like interacting CLARP kinase antibody, RIP-2 antibody, RIP-like-interacting CLARP kinase antibody, RIPK 2 antibody, Ripk2 antibody, RIPK2_HUMAN antibody, TNFRSF antibody, Tyrosine-protein kinase RIPK2 antibody, UNQ277/PRO314/PRO34092 antibody

    UniProt
    O43353
    Pathways
    T-Zell Rezeptor Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
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