ErbB2/Her2 Antikörper (AA 153-598)

Produktnummer ABIN7167461

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ErbB2/Her2 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ErbB2/Her2 Antikörper (AA 153-598) (ABIN7167461)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-ErbB2/Her2 Antikörper

Bindungsspezifität: AA 153-598

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Receptor tyrosine-protein kinase erbB-2 protein (153-598AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: ERBB2

Hintergrund:

Background: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Aliases: Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, C erb B2/neu protein antibody, CD340 antibody, CD340 antigen antibody, Cerb B2/neu protein antibody, CerbB2 antibody, Erb b2 receptor tyrosine kinase 2 antibody, ErbB-2 proto-oncogene antibody, ERBB2 antibody, ERBB2_HUMAN antibody, HER 2 antibody, HER 2/NEU antibody, HER2 antibody, Herstatin antibody, Human epidermal growth factor receptor 2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, MLN19 antibody, NEU antibody, NEU proto oncogene antibody, Neuro/glioblastoma derived oncogene homolog antibody, Neuroblastoma/glioblastoma derived oncogene homolog antibody, NGL antibody, p185erbB2 antibody, Proto-oncogene c-ErbB-2 antibody, Proto-oncogene Neu antibody, Receptor tyrosine-protein kinase erbB-2 antibody, TKR1 antibody, Tyrosine kinase type cell surface receptor HER2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody, V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

UniProt: P04626

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development