REST Antikörper (AA 250-350) (FITC)
Quick Overview for REST Antikörper (AA 250-350) (FITC) (ABIN7167427)
Target
Alle REST Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 250-350
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human RE1-silencing transcription factor protein (250-350AA)
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Isotyp
- IgG
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- REST (RE1-Silencing Transcription Factor (REST))
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Andere Bezeichnung
- REST
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Hintergrund
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Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Aliases: Neural Restrictive Silencer Factor antibody, Neural-restrictive silencer factor antibody, Neuron Restrictive Silencer Factor antibody, NRSF antibody, RE1 silencing transcription factor antibody, RE1-silencing transcription factor antibody, Repressor binding to the X2 box antibody, rest antibody, REST protein antibody, REST_HUMAN antibody, X2 box repressor antibody, XBR antibody
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UniProt
- Q13127
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Pathways
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
Target
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