R-Spondin 3 Antikörper (AA 22-272) (HRP)

Produktnummer ABIN7166939

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch R-Spondin 3 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für R-Spondin 3 Antikörper (AA 22-272) (HRP) (ABIN7166939)

Target: R-Spondin 3 (RSPO3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser R-Spondin 3 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-R-Spondin 3 Antikörper (HRP)

Bindungsspezifität: AA 22-272

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human R-spondin-3 protein (22-272AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Andere Bezeichnung: RSPO3

Hintergrund:

Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Aliases: CRISTIN1 antibody, hPWTSR antibody, hRspo3 antibody, Protein with TSP type-1 repeat antibody, PWTSR antibody, R-spondin 3 homolog antibody, R-spondin-3 [Precursor] antibody, R-spondin-3 antibody, Roof plate specific spondin-3 antibody, Roof plate-specific spondin-3 antibody, RSPO3 antibody, RSPO3_HUMAN antibody, Thrombospondin type I domain containing 2 antibody, Thrombospondin type-1 domain-containing protein 2 antibody, THSD2 antibody

UniProt: Q9BXY4