Ret Proto-Oncogene Antikörper (AA 29-300)

Produktnummer ABIN7166493

Der Kaninchen Polyklonal Anti-Ret Proto-Oncogene-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, Ret Proto-Oncogene in Proben von Human zu detektieren.

Kurzübersicht für Ret Proto-Oncogene Antikörper (AA 29-300) (ABIN7166493)

Target: Ret Proto-Oncogene (RET)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ret Proto-Oncogene Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Ret Proto-Oncogene Antikörper

Bindungsspezifität: AA 29-300

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Proto-oncogene tyrosine-protein kinase receptor Ret protein (29-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Andere Bezeichnung: RET

Hintergrund:

Background: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer\\\'s patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers, these diseases are characterized by aberrant integrins-regulated cell migration.

Aliases: C ret antibody, Cadherin family member 12 antibody, Cadherin related family member 16 antibody, CDHF 12 antibody, CDHF12 antibody, CDHR16 antibody, ELKS Fusion gene antibody, HSCR 1 antibody, HSCR1 antibody, Hydroxyaryl protein kinase antibody, MEN2A antibody, MEN2B antibody, MTC 1 antibody, MTC1 antibody, Multiple endocrine neoplasia and medullary thyroid carcinoma 1 antibody, Oncogene RET antibody, Proto oncogene tyrosine protein kinase receptor ret antibody, Proto-oncogene c-Ret antibody, Proto-oncogene tyrosine-protein kinase receptor ret antibody, PTC antibody, RET antibody, RET ELE1 antibody, Ret Proto oncogene antibody, RET transforming sequence antibody, RET_HUMAN antibody, RET51 antibody, RET9 antibody, tyrosine-protein kinase receptor ret antibody

UniProt: P07949

Pathways: RTK Signalweg, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation