TIMELESS Antikörper (AA 1004-1131)

Produktnummer ABIN7166187

Der Kaninchen Polyklonal Anti-TIMELESS-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, TIMELESS in Proben von Human zu detektieren.

Kurzübersicht für TIMELESS Antikörper (AA 1004-1131) (ABIN7166187)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMELESS Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TIMELESS Antikörper

Bindungsspezifität: AA 1004-1131

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protein timeless homolog protein (1004-1131AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Andere Bezeichnung: TIMELESS

Hintergrund:

Background: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Aliases: FLJ12640 antibody, FLJ20714 antibody, hTIM antibody, Protein timeless homolog antibody, TIM antibody, TIM_HUMAN antibody, TIM1 antibody, Timeless antibody, timeless circadian clock 1 antibody, timeless circadian clock antibody, timeless homolog antibody, TIMELESS1 antibody, Tof1 homolog antibody

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism