SAV1 Antikörper (AA 1-210)

Produktnummer ABIN7166096

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SAV1 in WB, ELISA, IHC, IF und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SAV1 Antikörper (AA 1-210) (ABIN7166096)

Target: SAV1 (Salvador Homolog 1 (SAV1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SAV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-SAV1 Antikörper

Bindungsspezifität: AA 1-210

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Protein salvador homolog 1 protein (1-210AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SAV1

Target: SAV1 (Salvador Homolog 1 (SAV1))

Andere Bezeichnung: SAV1

Hintergrund:

Background: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Aliases: 1700040G09Rik antibody, 45 kDa WW domain protein antibody, hWW 45 antibody, hWW45 antibody, Protein salvador homolog 1 antibody, salvador family WW domain containing protein 1 antibody, salvador homolog 1 (Drosophila) antibody, Salvador homolog 1 antibody, Salvador, Drosophila, homolog of antibody, SAV 1 antibody, SAV antibody, SAV1 antibody, SAV1_HUMAN antibody, WW 45 antibody, WW domain containing antibody, WW domain-containing adaptor 45 antibody, WW domain-containing protein, 45-KD antibody, WW45 antibody, WW45 protein antibody, WWP 4 antibody, WWP4 antibody

UniProt: Q9H4B6

Pathways: Stem Cell Maintenance