BICD2 Antikörper (AA 511-625)

Produktnummer ABIN7165140

Der Kaninchen Polyklonal Anti-BICD2-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, BICD2 in Proben von Human zu detektieren.

Kurzübersicht für BICD2 Antikörper (AA 511-625) (ABIN7165140)

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BICD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-BICD2 Antikörper

Bindungsspezifität: AA 511-625

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protein bicaudal D homolog 2 protein (511-625AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Andere Bezeichnung: BICD2

Hintergrund:

Background: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).

Aliases: bA526D8.1 antibody, Bic D 2 antibody, Bic-D 2 antibody, Bicaudal D homolog 2 (Drosophila) antibody, Bicaudal D homolog 2 antibody, Bicd2 antibody, BICD2_HUMAN antibody, Coiled coil protein BICD2 antibody, Cytoskeleton like bicaudal D protein homolog 2 antibody, Homolog of Drosophila bicaudal D antibody, KIAA0699 antibody, Protein bicaudal D homolog 2 antibody

UniProt: Q8TD16

Pathways: Maintenance of Protein Location