Neuregulin 1 Antikörper (AA 75-176)

Produktnummer ABIN7164301

Dieses Anti-Neuregulin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Neuregulin 1 in IHC, ELISA und IF. Geeignet für Human.

Kurzübersicht für Neuregulin 1 Antikörper (AA 75-176) (ABIN7164301)

Target: Neuregulin 1 (NRG1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Neuregulin 1 Antikörper

Bindungsspezifität: AA 75-176

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (75-176AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Neuregulin 1

Target: Neuregulin 1 (NRG1)

Andere Bezeichnung: NRG1

Hintergrund:

Background: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, stimulating Schwann cell proliferation, implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Aliases: Acetylcholine receptor-inducing activity antibody, Acetylcholine receptor-inducing activity, chick, homolog of antibody, ARIA antibody, Breast cancer cell differentiation factor p45 antibody, GGF antibody, GGF2 antibody, glial growth factor 2 antibody, Glial growth factor antibody, Heregulin antibody, heregulin, alpha (45kD, ERBB2 p185-activator) antibody, heregulin, alpha antibody, HGL antibody, HRG antibody, HRG1 antibody, HRGA antibody, MST131 antibody, MSTP131 antibody, NDF antibody, Neu differentiation factor antibody, Neuregulin-1 antibody, nrg1 antibody, NRG1-IT2 antibody, NRG1_HUMAN antibody, Pro-NRG1 antibody, Sensory and motor neuron-derived factor antibody, SMDF antibody

UniProt: Q02297

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation