PAI1 Antikörper (AA 24-398) (Biotin)

Produktnummer ABIN7163533

Dieses Anti-PAI1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PAI1 in ELISA. Geeignet für Human.

Kurzübersicht für PAI1 Antikörper (AA 24-398) (Biotin) (ABIN7163533)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAI1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-PAI1 Antikörper (Biotin)

Bindungsspezifität: AA 24-398

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Andere Bezeichnung: SERPINE1

Hintergrund:

Background: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).

Aliases: Clade E antibody, Endothelial plasminogen activator inhibitor antibody, Nexin antibody, Nexin plasminogen activator inhibitor type 1 antibody, PAI 1 antibody, PAI antibody, PAI-1 antibody, PAI1_HUMAN antibody, PLANH1 antibody, Plasminogen activator inhibitor 1 antibody, Plasminogen activator inhibitor type 1 antibody, Serine (or cysteine) proteinase inhibitor antibody, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody, Serine proteinase inhibitor clade E member 1 antibody, serpin antibody, Serpin E1 antibody, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody, Serpin peptidase inhibitor clade E antibody, Serpine 1 antibody, SERPINE1 antibody

UniProt: P05121

Pathways: p53 Signalweg, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration