PIWIL4 Antikörper (AA 12-235) (HRP)

Produktnummer ABIN7163481

Der Kaninchen Polyklonal Anti-PIWIL4-Antikörper wurde für ELISA validiert. Er ist geeignet, PIWIL4 in Proben von Human zu detektieren.

Kurzübersicht für PIWIL4 Antikörper (AA 12-235) (HRP) (ABIN7163481)

Target: PIWIL4 (Piwi-Like 4 (PIWIL4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIWIL4 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-PIWIL4 Antikörper (HRP)

Bindungsspezifität: AA 12-235

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Piwi-like protein 4 protein (12-235AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIWIL4

Target: PIWIL4 (Piwi-Like 4 (PIWIL4))

Andere Bezeichnung: PIWIL4

Hintergrund:

Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing \'Lys-9\' methylation of histone H3 at some loci (PubMed:12906857).

Aliases: DKFZp686P01248 antibody, FLJ36156 antibody, HILI 2 antibody, HILI2 antibody, HIWI 2 antibody, HIWI2 antibody, Miwi 2 protein antibody, Miwi2 antibody, PIWI antibody, Piwi like 2 antibody, Piwi like 4 (Drosophila) antibody, Piwi like 4 antibody, Piwi like protein 4 antibody, PIWI like protein antibody, Piwi like RNA mediated gene silencing 4 antibody, Piwi-like protein 4 antibody, PIWIL 4 antibody, Piwil4 antibody, PIWL4_HUMAN antibody

UniProt: Q7Z3Z4