PPIF Antikörper (AA 30-207)

Produktnummer ABIN7162809

Der Kaninchen Polyklonal Anti-PPIF-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, PPIF in Proben von Human zu detektieren.

Kurzübersicht für PPIF Antikörper (AA 30-207) (ABIN7162809)

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPIF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-PPIF Antikörper

Bindungsspezifität: AA 30-207

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Peptidyl-prolyl cis-trans isomerase F, mitochondrial protein (30-207AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PPIF

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Andere Bezeichnung: PPIF

Hintergrund:

Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Aliases: Cyclophilin 3 antibody, cyclophilin D antibody, Cyclophilin F antibody, Cyp D antibody, CyP M antibody, CyP-D antibody, CyP-M antibody, CYP3 antibody, CypD antibody, hCyP3 antibody, mitochondrial antibody, Mitochondrial cyclophilin antibody, Peptidyl prolyl cis trans isomerase, mitochondral antibody, Peptidyl-prolyl cis-trans isomerase F antibody, Peptidyl-prolyl cis-trans isomerase F, mitochondrial antibody, Peptidylprolyl isomerase F (cyclophilin F) antibody, Peptidylprolyl isomerase F antibody, PPIase antibody, PPIase F antibody, Ppif antibody, PPIF_HUMAN antibody, Rotamase antibody, Rotamase F antibody

UniProt: P30405

Pathways: Proton Transport, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity