PPIF Antikörper (Internal Region)

Produktnummer ABIN6258097

Produktdetails anti-PPIF Antikörper

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPIF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PPIF Antibody detects endogenous levels of total PPIF.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PPIF, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PPIF

Target: PPIF (Peptidylprolyl Isomerase F (PPIF))

Andere Bezeichnung: PPIF (PPIF Produkte)

Synonyme: CYP3 antikoerper, CyP-M antikoerper, Cyp-D antikoerper, CypD antikoerper, CyP-D antikoerper, ppif antikoerper, wu:fd61c06 antikoerper, zgc:101753 antikoerper, AW457192 antikoerper, CyP-F antikoerper, PPIase antikoerper, Cyp-40 antikoerper, cypf antikoerper, peptidylprolyl isomerase F antikoerper, peptidylprolyl isomerase Fa antikoerper, peptidylprolyl isomerase F (cyclophilin F) antikoerper, peptidylprolyl isomerase D antikoerper, peptidylprolyl isomerase F L homeolog antikoerper, PPIF antikoerper, ppifa antikoerper, Ppif antikoerper, Ppid antikoerper, ppif antikoerper, ppif.L antikoerper

Hintergrund:

Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Gene: PPIF

Molekulargewicht: 22 kDa

Gen-ID: 10105

UniProt: P30405

Pathways: Proton Transport, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity