NPC1 Antikörper (AA 23-269)

Produktnummer ABIN7161727

Dieses Anti-NPC1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NPC1 in ELISA, WB und IHC. Geeignet für Human.

Kurzübersicht für NPC1 Antikörper (AA 23-269) (ABIN7161727)

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPC1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NPC1 Antikörper

Bindungsspezifität: AA 23-269

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NPC intracellular cholesterol transporter 1 protein (23-269AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Andere Bezeichnung: NPC1

Hintergrund:

Background: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.

Aliases: Niemann Pick C1 protein precursor antibody, Niemann Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC antibody, NPC1 antibody, NPC1_HUMAN antibody

UniProt: O15118