ULBP2 Antikörper (AA 26-216)

Produktnummer ABIN7161653

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ULBP2 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ULBP2 Antikörper (AA 26-216) (ABIN7161653)

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULBP2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ULBP2 Antikörper

Bindungsspezifität: AA 26-216

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human NKG2D ligand 2 protein (26-216AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ULBP2

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Andere Bezeichnung: ULBP2

Hintergrund:

Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Aliases: ALCAN alpha antibody, ALCAN-alpha antibody, N2DL 2 antibody, N2DL-2 antibody, N2DL2 antibody, N2DL2_HUMAN antibody, NKG2D ligand 2 antibody, NKG2D ligand 2 precursor antibody, NKG2DL2 antibody, RAET1H antibody, Retinoic acid early transcript 1 H antibody, Retinoic acid early transcript 1H antibody, UL16 binding protein 2 antibody, UL16-binding protein 2 antibody, ULBP2 antibody

UniProt: Q9BZM5