NAE1 Antikörper (Regulatory Subunit)

Produktnummer ABIN7161137

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NAE1 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NAE1 Antikörper (Regulatory Subunit) (ABIN7161137)

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-NAE1 Antikörper

Bindungsspezifität: AA 1-220, Regulatory Subunit

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human NEDD8-activating enzyme E1 regulatory subunit protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NAE1

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Andere Bezeichnung: NAE1

Hintergrund:

Background: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Aliases: 59 kDa antibody, A 116A10.1 antibody, Amyloid beta precursor protein binding protein 1 59kD antibody, Amyloid beta precursor protein binding protein 1 59 kDa antibody, Amyloid beta precursor protein binding protein 1 antibody, Amyloid beta precursor protein binding protein 1, 59 kDa antibody, Amyloid beta precursor protein-binding protein 1 antibody, Amyloid protein binding protein 1 antibody, Amyloid protein-binding protein 1 antibody, APP BP1 antibody, APP-BP1 antibody, APPBP 1 antibody, APPBP1 antibody, HPP 1 antibody, HPP1 antibody, NAE 1 antibody, NAE1 antibody, NEDD8 activating enzyme E1 regulatory subunit antibody, NEDD8 activating enzyme E1 subunit 1 antibody, NEDD8 activating enzyme E1 subunit antibody, NEDD8-activating enzyme E1 regulatory subunit antibody, Proto oncogene protein 1 antibody, Proto-oncogene protein 1 antibody, Protooncogene protein 1 antibody, ula 1 antibody, ULA1_HUMAN antibody

UniProt: Q13564