MAD2L2 Antikörper (AA 1-211) (FITC)

Produktnummer ABIN7160096

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAD2L2 in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MAD2L2 Antikörper (AA 1-211) (FITC) (ABIN7160096)

Target: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAD2L2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-MAD2L2 Antikörper (FITC)

Bindungsspezifität: AA 1-211

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mitotic spindle assembly checkpoint protein MAD2B protein (1-211AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAD2L2

Target: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Andere Bezeichnung: MAD2L2

Hintergrund:

Background: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Aliases: Homolog of REV7 S cerevisiae antibody, hREV7 antibody, MAD2 (mitotic arrest deficient yeast, homolog) like 2 antibody, MAD2 homolog antibody, MAD2 like 2 antibody, MAD2 mitotic arrest deficient like 2 antibody, MAD2-like protein 2 antibody, MAD2B antibody, Mad2l2 antibody, MD2L2_HUMAN antibody, Mitotic Arrest Deficient 2 L2 antibody, Mitotic arrest deficient 2-like protein 2 antibody, Mitotic arrest deficient homolog like 2 antibody, Mitotic arrest deficient like 2 (yeast) antibody, Mitotic arrest deficient yeast homolog antibody, Mitotic spindle assembly checkpoint protein MAD2B antibody, Polymerase (DNA directed) zeta 2 accessory subunit antibody, POLZ2 antibody, REV 7 antibody, REV7 antibody, REV7 homolog antibody, Weakly similar to Mitotic MAD2 protein (S cerevisiae) antibody

UniProt: Q9UI95