Rekombinanter MAD2L2 Antikörper

Produktnummer ABIN7127607

Produktdetails anti-MAD2L2 Antikörper

Target: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MAD2L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Mad2L2

Klon: 4D8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAD2L2

Target: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Andere Bezeichnung: MAD2L2 (MAD2L2 Produkte)

Synonyme: mad2b antikoerper, 2310033C13Rik antikoerper, MAD2B antikoerper, REV7 antikoerper, mad2B antikoerper, mad2l2-A antikoerper, xMAD2L2 antikoerper, POLZ2 antikoerper, mad2l2 antikoerper, zgc:110299 antikoerper, mitotic arrest deficient 2 like 2 antikoerper, MAD2 mitotic arrest deficient-like 2 antikoerper, mitotic arrest deficient 2 like 2 S homeolog antikoerper, MAD2 mitotic arrest deficient-like 2 (yeast) antikoerper, si:dkey-23c22.2 antikoerper, mad2l2 antikoerper, MAD2L2 antikoerper, Mad2l2 antikoerper, mad2l2.S antikoerper, si:dkey-23c22.2 antikoerper

Hintergrund:

Background: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Aliases: Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7), MAD2L2, MAD2B REV7

UniProt: Q9UI95