MBTPS1 Antikörper (AA 187-400)

Produktnummer ABIN7159373

Produktdetails anti-MBTPS1 Antikörper

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Bindungsspezifität: AA 187-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBTPS1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Membrane-bound transcription factor site-1 protease protein (187-400aa)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Andere Bezeichnung: MBTPS1 (MBTPS1 Produkte)

Hintergrund:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Aliases: Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1), MBTPS1, KIAA0091 S1P SKI1

UniProt: Q14703

Pathways: ER-Nucleus Signaling