MBTPS1 Antikörper (AA 187-400)
Kurzübersicht für MBTPS1 Antikörper (AA 187-400) (ABIN7159372)
Target
Alle MBTPS1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 187-400
-
Kreuzreaktivität
- Human
-
Aufreinigung
- >95%, Protein G purified
-
Immunogen
- Recombinant Human Membrane-bound transcription factor site-1 protease protein (187-400aa)
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- Recommended dilution: IHC:1:100-1:500,
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
-
Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C,-80 °C
-
Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))
-
Andere Bezeichnung
- MBTPS1
-
Hintergrund
-
Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
Aliases: Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1), MBTPS1, KIAA0091 S1P SKI1
-
UniProt
- Q14703
-
Pathways
- ER-Nucleus Signaling
Target
-