MAML1 Antikörper (AA 1-45) (Biotin)

Produktnummer ABIN7159034

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAML1 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MAML1 Antikörper (AA 1-45) (Biotin) (ABIN7159034)

Target: MAML1 (Mastermind-Like 1 (MAML1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAML1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-MAML1 Antikörper (Biotin)

Bindungsspezifität: AA 1-45

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mastermind-like protein 1 protein (1-45AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Andere Bezeichnung: MAML1

Hintergrund:

Background: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Aliases: Mam-1 antibody, Mam1 antibody, MAML 1 antibody, Maml1 antibody, MAML1_HUMAN antibody, Mastermind like 1 antibody, Mastermind-like protein 1 antibody

UniProt: Q92585

Pathways: Notch Signalweg, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development