LPAR1 Antikörper (AA 316-364) (Biotin)

Produktnummer ABIN7158745

Dieses Anti-LPAR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LPAR1 in ELISA. Geeignet für Human.

Kurzübersicht für LPAR1 Antikörper (AA 316-364) (Biotin) (ABIN7158745)

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPAR1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-LPAR1 Antikörper (Biotin)

Bindungsspezifität: AA 316-364

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Lysophosphatidic acid receptor 1 protein (316-364AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LPAR1

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Andere Bezeichnung: LPAR1

Hintergrund:

Background: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA, this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Aliases: 5031439C20 antibody, AI326300 antibody, EDG 2 antibody, EDG2 antibody, Endothelial differentiation gene 2 antibody, Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody, GPCR 26 antibody, Gpcr26 antibody, Gpcr91 antibody, GPR26 antibody, Kdt2 antibody, LPA 1 antibody, LPA receptor 1 antibody, LPA receptor EDG2 antibody, LPA-1 antibody, lpA1 antibody, Lpar1 antibody, LPAR1_HUMAN antibody, Lysophosphatidic acid receptor 1 antibody, Lysophosphatidic acid receptor Edg-2 antibody, Lysophosphatidic acid receptor EDG2 antibody, MGC105279 antibody, MGC29102 antibody, Mrec1.3 antibody, rec.1.3 antibody, Ventricular zone gene 1 antibody, vzg-1 antibody, VZG1 antibody

UniProt: Q92633

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration