KLHL12 Antikörper (AA 1-220)

Produktnummer ABIN7157267

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLHL12 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für KLHL12 Antikörper (AA 1-220) (ABIN7157267)

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL12 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-KLHL12 Antikörper

Bindungsspezifität: AA 1-220

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 12 protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KLHL12

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Andere Bezeichnung: KLHL12

Hintergrund:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

Aliases: C3IP1 antibody, CUL3 interacting protein 1 antibody, CUL3-interacting protein 1 antibody, DKIR antibody, DKIR homolog antibody, FLJ27152 antibody, hDKIR antibody, Kelch like 12 (Drosophila) antibody, Kelch like 12 antibody, Kelch like 12 variant antibody, Kelch like protein 12 antibody, Kelch like protein C3IP1 antibody, kelch-like family member 12 antibody, Kelch-like protein 12 antibody, KLH12_HUMAN antibody, KLHL 12 antibody, klhl12 antibody, OTTHUMP00000038799 antibody

UniProt: Q53G59