Inversin Antikörper (AA 1-101)

Produktnummer ABIN7157008

Dieses Anti-Inversin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Inversin in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für Inversin Antikörper (AA 1-101) (ABIN7157008)

Target: Inversin (INVS)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Inversin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Inversin Antikörper

Bindungsspezifität: AA 1-101

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Inversin protein (1-101AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Inversin

Target: Inversin (INVS)

Andere Bezeichnung: INVS

Hintergrund:

Background: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).

Aliases: INVS antibody, INV antibody, NPHP2 antibody, Inversin antibody, Inversion of embryo turning homolog antibody, Nephrocystin-2 antibody

UniProt: Q9Y283