IL28B Antikörper (AA 22-196)

Produktnummer ABIN7156612

Dieses Anti-IL28B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL28B in ELISA und IHC. Geeignet für Human.

Kurzübersicht für IL28B Antikörper (AA 22-196) (ABIN7156612)

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL28B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-IL28B Antikörper

Bindungsspezifität: AA 22-196

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Interferon lambda-3 protein (22-196AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu IL28B

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Andere Bezeichnung: IFNL3

Hintergrund:

Background: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Aliases: Cytokine ZCYTO22 antibody, IFN-lambda-3 antibody, IFN-lambda-4 antibody, IL-28B antibody, IL-28C antibody, IL28B antibody, IL28B_HUMAN antibody, IL28C antibody, Interferon lambda-3 antibody, Interferon lambda-4 antibody, interleukin 28B (interferon, lambda 3) antibody, Interleukin 28C antibody, Interleukin-28B antibody, Interleukin-28C antibody

UniProt: Q8IZI9