INSIG1 Antikörper (AA 1-87)

Produktnummer ABIN7156348

Dieses Anti-INSIG1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von INSIG1 in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für INSIG1 Antikörper (AA 1-87) (ABIN7156348)

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-INSIG1 Antikörper

Bindungsspezifität: AA 1-87

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Insulin-induced gene 1 protein (1-87AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Andere Bezeichnung: INSIG1

Hintergrund:

Background: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Aliases: CL 6 antibody, CL6 antibody, INSI1_HUMAN antibody, INSIG 1 antibody, INSIG 1 membrane protein antibody, INSIG-1 antibody, insig1 antibody, INSIG1 membrane protein antibody, Insulin induced gene 1 antibody, Insulin induced gene 1 protein antibody, Insulin-induced gene 1 protein antibody, MGC1405 antibody

UniProt: O15503

Pathways: ER-Nucleus Signaling