KPNB1 Antikörper (AA 9-214) (Biotin)

Produktnummer ABIN7156135

Dieses Anti-KPNB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KPNB1 in ELISA. Geeignet für Human.

Kurzübersicht für KPNB1 Antikörper (AA 9-214) (Biotin) (ABIN7156135)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNB1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-KPNB1 Antikörper (Biotin)

Bindungsspezifität: AA 9-214

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Importin subunit beta-1 protein (9-214AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Andere Bezeichnung: KPNB1

Hintergrund:

Background: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Aliases: IMB 1 antibody, IMB1 antibody, IMB1_HUMAN antibody, Impnb antibody, Importin 90 antibody, Importin beta 1 antibody, Importin beta 1 subunit antibody, Importin subunit beta-1 antibody, Importin-90 antibody, IPOB antibody, Karyopherin beta 1 antibody, Karyopherin beta 1 subunit antibody, Karyopherin subunit beta-1 antibody, KPNB 1 antibody, Kpnb1 antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF 97 antibody, NTF97 antibody, NTF97/Importin beta antibody, Nuclear factor P97 antibody, Pore targeting complex 97 kDa subunit antibody, PTAC97 antibody

UniProt: Q14974

Pathways: Protein targeting to Nucleus