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IGHM Antikörper (AA 45-178)

Der Kaninchen Polyklonal Anti-IGHM-Antikörper wurde für IHC, WB und ELISA validiert. Er ist geeignet, IGHM in Proben von Human zu detektieren.
Produktnummer ABIN7156089

Kurzübersicht für IGHM Antikörper (AA 45-178) (ABIN7156089)

Target

IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Reaktivität

  • 27
  • 1
  • 1
Human

Wirt

  • 14
  • 13
Kaninchen

Klonalität

  • 18
  • 9
Polyklonal

Konjugat

  • 23
  • 1
  • 1
  • 1
  • 1
Dieser IGHM Antikörper ist unkonjugiert

Applikation

  • 14
  • 13
  • 11
  • 8
  • 7
  • 7
  • 6
  • 4
  • 2
  • 1
  • 1
Immunohistochemistry (IHC), Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 45-178

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Immunoglobulin heavy constant mu protein (45-178AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    IGHM (Immunoglobulin Heavy Constant mu (IGHM))

    Andere Bezeichnung

    IGHM

    Hintergrund

    Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).

    Aliases: IGHMImmunoglobulin heavy constant mu antibody, Ig mu chain C region antibody, Ig mu chain C region BOT antibody, Ig mu chain C region GAL antibody, Ig mu chain C region OU antibody

    UniProt

    P01871
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