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HIC1 Antikörper (AA 297-418)

This anti-HIC1 antibody (ABIN7156016) is a Rabbit Polyclonal antibody detecting HIC1 in ELISA, IHC. Suitable for Human.
Produktnummer ABIN7156016

Quick Overview for HIC1 Antikörper (AA 297-418) (ABIN7156016)

Target

Alle HIC1 Antikörper anzeigen
HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität

  • 26
  • 20
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 38
  • 4
  • 1
Kaninchen

Klonalität

  • 39
  • 4
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HIC1 Antikörper ist unkonjugiert

Applikation

  • 38
  • 19
  • 13
  • 13
  • 3
  • 3
  • 3
  • 2
  • 1
ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 297-418

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Hypermethylated in cancer 1 protein (297-418AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:200-1:500,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    HIC1 (Hypermethylated in Cancer 1 (HIC1))

    Andere Bezeichnung

    HIC1

    Hintergrund

    Background: Transcriptional repressor. Recognizes and binds to the consensus sequence \\\'5-[CG]NG[CG]GGGCA[CA]CC-3\\\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

    Aliases: Hic 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, Hic-1 antibody, Hic1 antibody, HIC1_HUMAN antibody, Hypermethylated in cancer 1 antibody, Hypermethylated in cancer 1 protein antibody, ZBTB29 antibody, Zinc finger and BTB domain-containing protein 29 antibody, ZNF901 antibody

    UniProt

    Q14526

    Pathways

    Positive Regulation of Response to DNA Damage Stimulus
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