HIC1 Antikörper (AA 297-418)

Produktnummer ABIN7156016

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HIC1 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HIC1 Antikörper (AA 297-418) (ABIN7156016)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIC1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-HIC1 Antikörper

Bindungsspezifität: AA 297-418

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Hypermethylated in cancer 1 protein (297-418AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Andere Bezeichnung: HIC1

Hintergrund:

Background: Transcriptional repressor. Recognizes and binds to the consensus sequence \\\'5-[CG]NG[CG]GGGCA[CA]CC-3\\\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Aliases: Hic 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, Hic-1 antibody, Hic1 antibody, HIC1_HUMAN antibody, Hypermethylated in cancer 1 antibody, Hypermethylated in cancer 1 protein antibody, ZBTB29 antibody, Zinc finger and BTB domain-containing protein 29 antibody, ZNF901 antibody

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus