HIC1 Antikörper (Middle Region)

Produktnummer ABIN2780783

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-HIC1 Antikörper wird verwendet zum Nachweis von HIC1 in Proben von Human, Ratte, Maus, Meerschweinchen, Hund, Rind (Kuh) und Pferd. Er wurde validiert für WB.

Kurzübersicht für HIC1 Antikörper (Middle Region) (ABIN2780783)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Hund, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HIC1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: HIC1 Antibody - middle region

Sequenz: GETPIAVMGE FANLATSLNP LDPDKDEEEE EEEESEDELP QDISLAAGGE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HIC1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38806-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HIC1 Antikörper (ABIN2780783)

Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: "Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma." in: Oncogene, Vol. 27, Issue 18, pp. 2613-25, (2008) (PubMed).

Details zu HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Andere Bezeichnung: HIC1

Hintergrund:

Background Information: HIC1 is a transcriptional repressor. HIC1 may act as a tumor suppressor. HIC1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney.

Gene Name: Hypermethylated in cancer 1

Alternative Symbols: hic-1, ZBTB29, ZNF901

Protein Name: Hypermethylated in cancer 1 protein

Molekulargewicht: 74kDa

Gen-ID: 3090

NCBI Accession: NP_006488

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus