SIX Homeobox 1 Antikörper (AA 144-262) (HRP)

Produktnummer ABIN7155851

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIX Homeobox 1 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SIX Homeobox 1 Antikörper (AA 144-262) (HRP) (ABIN7155851)

Target: SIX Homeobox 1 (SIX1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIX Homeobox 1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-SIX Homeobox 1 Antikörper (HRP)

Bindungsspezifität: AA 144-262

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Homeobox protein SIX1 protein (144-262AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIX Homeobox 1

Target: SIX Homeobox 1 (SIX1)

Andere Bezeichnung: SIX1

Hintergrund:

Background: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5\'-TCA[AG][AG]TTNC-3\' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Aliases: BOS3 antibody, DFNA23 antibody, Homeobox protein SIX1 antibody, OTTHUMP00000179042 antibody, Sine oculis homeobox homolog 1 antibody, SIX homeobox 1 antibody, SIX1 antibody, SIX1_HUMAN antibody, TIP39 antibody

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development