SIP1 Antikörper (AA 1-280)

Produktnummer ABIN7153753

Dieses Anti-SIP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIP1 in WB, ELISA, IF und IP. Geeignet für Human.

Kurzübersicht für SIP1 Antikörper (AA 1-280) (ABIN7153753)

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-SIP1 Antikörper

Bindungsspezifität: AA 1-280

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Gem-associated protein 2 protein (1-280AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIP1

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Andere Bezeichnung: GEMIN2

Hintergrund:

Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Aliases: Component of gems 2 antibody, Gem (nuclear organelle) associated protein 2 antibody, Gem associated protein 2 antibody, GEMI2_HUMAN antibody, Gemin-2 antibody, gemin2 antibody, SIP 1 antibody, SIP-1 antibody, SIP1 antibody, SIP1 delta antibody, SIP1-delta antibody, SMN interacting protein 1 antibody, SMN interacting protein 1 delta antibody, SMN-interacting protein 1 antibody, Survival interacting protein 1 antibody, Survival of motor neuron protein interacting protein 1 antibody, Survival of motor neuron protein-interacting protein 1 antibody

UniProt: O14893

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation