FZD8 Antikörper (AA 55-233) (HRP)

Produktnummer ABIN7153196

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FZD8 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FZD8 Antikörper (AA 55-233) (HRP) (ABIN7153196)

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD8 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-FZD8 Antikörper (HRP)

Bindungsspezifität: AA 55-233

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Frizzled-8 protein (55-233AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FZD8

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Andere Bezeichnung: FZD8

Hintergrund:

Background: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Aliases: Frizzled 8 seven transmembrane spanning receptor antibody, frizzled 8, seven transmembrane spanning receptor antibody, Frizzled family receptor 8 antibody, frizzled homolog 8 (Drosophila) antibody, Frizzled homolog 8 antibody, Frizzled-8 antibody, FZ 8 antibody, Fz-8 antibody, FZ8 antibody, FZD 8 antibody, FZD8 antibody, FZD8_HUMAN antibody, hFZ 8 antibody, hFz8 antibody, HGNC4046 antibody, Homolog of Drosophila Frizzled 8 antibody

UniProt: Q9H461

Pathways: WNT Signalweg