FZR1 Antikörper (AA 1-493)

Produktnummer ABIN7152956

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FZR1 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FZR1 Antikörper (AA 1-493) (ABIN7152956)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FZR1 Antikörper

Bindungsspezifität: AA 1-493

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Fizzy-related protein homolog protein (1-493AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR1

Hintergrund:

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Aliases: CDC20 like 1b antibody, CDC20 like protein 1 antibody, CDC20-like protein 1 antibody, CDC20C antibody, CDH1 antibody, Cdh1/Hct1 homolog antibody, Fizzy related protein 1 antibody, Fizzy related protein antibody, Fizzy related protein homolog antibody, Fizzy-related protein homolog antibody, Fizzy/cell division cycle 20 related 1 antibody, FYR antibody, FZR 1 antibody, FZR 2 antibody, Fzr antibody, FZR_HUMAN antibody, Fzr1 antibody, Fzr1 protein antibody, FZR2 antibody, HCDH 1 antibody, HCDH antibody, hCDH1 antibody, KIAA1242 antibody

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA