FGFR2 Antikörper (AA 577-821) (FITC)

Produktnummer ABIN7152835

Dieses Anti-FGFR2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FGFR2 in . Geeignet für Human.

Kurzübersicht für FGFR2 Antikörper (AA 577-821) (FITC) (ABIN7152835)

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-FGFR2 Antikörper (FITC)

Bindungsspezifität: AA 577-821

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Fibroblast growth factor receptor 2 protein (577-821AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FGFR2

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Andere Bezeichnung: FGFR2

Hintergrund:

Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Aliases: bacteria-expressed kinase antibody, BBDS antibody, BEK antibody, BEK fibroblast growth factor receptor antibody, BFR1 antibody, CD332 antibody, CD332 antigen antibody, CEK3 antibody, CFD1 antibody, Craniofacial dysostosis 1 antibody, ECT1 antibody, FGF receptor antibody, FGFR 2 antibody, FGFR-2 antibody, Fgfr2 antibody, FGFR2_HUMAN antibody, Fibroblast growth factor receptor 2 antibody, Hydroxyaryl protein kinase antibody, Jackson Weiss syndrome antibody, JWS antibody, K SAM antibody, K-sam antibody, Keratinocyte growth factor receptor 2 antibody, Keratinocyte growth factor receptor antibody, KGFR antibody, KSAM antibody, protein tyrosine kinase, receptor like 14 antibody, soluble FGFR4 variant 4 antibody, TK14 antibody, TK25 antibody

UniProt: P21802

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding