EYA3 Antikörper (AA 1-300)

Produktnummer ABIN7152363

Der Kaninchen Polyklonal Anti-EYA3-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, EYA3 in Proben von Human zu detektieren.

Kurzübersicht für EYA3 Antikörper (AA 1-300) (ABIN7152363)

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-EYA3 Antikörper

Bindungsspezifität: AA 1-300

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Eyes absent homolog 3 protein (1-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EYA3

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Andere Bezeichnung: EYA3

Hintergrund:

Background: Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.

Aliases: AI844637 antibody, DKFZp686C132 antibody, EYA3 antibody, EYA3_HUMAN antibody, Eyes absent 3 antibody, Eyes absent 3 homolog (Drosophila) antibody, Eyes absent homolog 3 antibody, OTTMUSP00000010370 antibody, RP11-460I13.4 antibody, RP23-442A20.1 antibody

UniProt: Q99504

Pathways: Positive Regulation of Response to DNA Damage Stimulus