EPH Receptor A2 Antikörper (AA 627-976)

Produktnummer ABIN7151835

Der Kaninchen Polyklonal Anti-EPH Receptor A2-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, EPH Receptor A2 in Proben von Human zu detektieren.

Kurzübersicht für EPH Receptor A2 Antikörper (AA 627-976) (ABIN7151835)

Target: EPH Receptor A2 (EPHA2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-EPH Receptor A2 Antikörper

Bindungsspezifität: AA 627-976

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ephrin type-A receptor 2 protein (627-976AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EPHA2

Hintergrund:

Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Aliases: ARCC2 antibody, AW545284 antibody, CTPA antibody, CTPP1 antibody, CTRCT6 antibody, EC 2.7.10.1 antibody, Eck antibody, Eph receptor A2 antibody, EPHA2 antibody, EPHA2_HUMAN antibody, Ephrin receptor antibody, Ephrin receptor EphA2 antibody, Ephrin type A receptor 2 antibody, Ephrin type-A receptor 2 antibody, Epithelial cell kinase antibody, Epithelial cell receptor protein tyrosine kinase antibody, Myk 2 antibody, Myk2 antibody, Sek 2 antibody, Sek2 antibody, Soluble EPHA2 variant 1 antibody, Tyrosine protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor MPK-5 antibody, Tyrosine-protein kinase receptor SEK-2 antibody

UniProt: P29317

Pathways: RTK Signalweg