RFFL Antikörper (AA 1-190)

Produktnummer ABIN7151117

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RFFL in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RFFL Antikörper (AA 1-190) (ABIN7151117)

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFFL Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RFFL Antikörper

Bindungsspezifität: AA 1-190

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase rififylin protein (1-190AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Andere Bezeichnung: RFFL

Hintergrund:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates \\\'Lys-48\\\'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.

Aliases: CARP-2 antibody, CARP2 antibody, Caspase regulator CARP2 antibody, Caspases 8 and 10 associated RING finger protein 2 antibody, caspases-8 and -10- associated RING finger protein 2 antibody, Caspases-8 and -10-associated RING finger protein 2 antibody, E3 ubiquitin protein ligase rififylin antibody, E3 ubiquitin-protein ligase rififylin antibody, Fring antibody, FYVE RING finger protein Sakura antibody, FYVE-RING finger protein Sakura antibody, Rffl antibody, RFFL_HUMAN antibody, Rififylin antibody, RING finger and FYVE like domain containing protein antibody, RING finger and FYVE-like domain-containing protein 1 antibody, RING finger protein 189 antibody, RING finger protein 34 like antibody, RING finger protein 34-like antibody, RNF189 antibody, RNF34L antibody

UniProt: Q8WZ73