RFFL Antikörper (C-Term)

Produktnummer ABIN1881744

Produktdetails anti-RFFL Antikörper

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Bindungsspezifität: AA 265-294, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFFL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RFFL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human RFFL.

Klon: RB40306

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RFFL Antikörper (ABIN1881744)

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Newton-Cheh, Eijgelsheim, Rice, de Bakker, Yin, Estrada, Bis, Marciante, Rivadeneira, Noseworthy, Sotoodehnia, Smith, Rotter, Kors, Witteman, Hofman, Heckbert: "Common variants at ten loci influence QT interval duration in the QTGEN Study." in: Nature genetics, Vol. 41, Issue 4, pp. 399-406, (2009) (PubMed).

Hosgood, Zhang, Shen, Berndt, Vermeulen, Li, Yin, Yeager, Yuenger, Rothman, Chanock, Smith, Lan: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, (2009) (PubMed).

Liao, Xiao, Tchikov, Fujita, Yang, Wincovitch, Garfield, Conze, El-Deiry, Schütze, Srinivasula: "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation." in: Current biology : CB, Vol. 18, Issue 9, pp. 641-9, (2008) (PubMed).

Yang, Dicker, Chen, El-Deiry: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, (2008) (PubMed).

Details zu RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Andere Bezeichnung: RFFL (RFFL Produkte)

Synonyme: MGC84042 antikoerper, RFFL antikoerper, Rffl antikoerper, 1700051E09Rik antikoerper, 4930516L10Rik antikoerper, BG080975 antikoerper, Carp2 antikoerper, CARP-2 antikoerper, CARP2 antikoerper, FRING antikoerper, RIFIFYLIN antikoerper, RNF189 antikoerper, RNF34L antikoerper, ring finger and FYVE like domain containing E3 ubiquitin protein ligase antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog antikoerper, ring finger and FYVE-like domain containing 1 antikoerper, ring finger and FYVE like domain containing protein antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase antikoerper, RFFL antikoerper, rffl.L antikoerper, Rffl antikoerper

Hintergrund: RFFL has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

Molekulargewicht: 40514

NCBI Accession: NP_001017368

UniProt: Q8WZ73