ITCH Antikörper (AA 29-303)

Produktnummer ABIN7151041

Dieses Anti-ITCH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ITCH in ELISA, WB und IF. Geeignet für Human.

Kurzübersicht für ITCH Antikörper (AA 29-303) (ABIN7151041)

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITCH Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-ITCH Antikörper

Bindungsspezifität: AA 29-303

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase Itchy homolog protein (29-303AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ITCH

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Andere Bezeichnung: ITCH

Hintergrund:

Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes \'Lys-29\'-, \'Lys-48\'- and \'Lys-63\'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates \'Lys-63\' polyubiquitin chains on RIPK1 and catalyzes the formation of \'Lys-48\'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by \'Lys-63\'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by \'Lys-63\' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation (By similarity). Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through \'Lys-48\'-linked conjugation resulting in MAVS proteasomal degradation. Ubiquitinates MAP3K7 through \'Lys-48\'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through \'Lys-29\'-linked polyubiquitination. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).

Aliases: ADMFD antibody, AIF4 antibody, AIP4 antibody, Atrophin 1 interacting protein 4 antibody, Atrophin-1-interacting protein 4 antibody, dJ468O1.1 antibody, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody, dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody, E3 ubiquitin protein ligase Itchy homolog antibody, E3 ubiquitin-protein ligase Itchy homolog antibody, EC 6.3.2 antibody, Itch antibody, ITCH_HUMAN antibody, Itchy E3 ubiquitin protein ligase antibody, Itchy E3 ubiquitin protein ligase homolog antibody, Itchy E3 ubiquitin protein ligase homolog mouse antibody, Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody, Itchy homolog E3 ubiquitin protein ligase antibody, Itchy mouse homolog E3 ubiquitin protein ligase antibody, NAPP1 antibody, NFE2 associated polypeptide 1 antibody, NFE2-associated polypeptide 1 antibody, Ubiquitin protein ligase ITCH antibody

UniProt: Q96J02

Pathways: Activation of Innate immune Response, CXCR4-mediated Signaling Events