PIAS1 Antikörper (AA 422-651)

Produktnummer ABIN7150963

Dieses Anti-PIAS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PIAS1 in IHC und ELISA. Geeignet für Human.

Kurzübersicht für PIAS1 Antikörper (AA 422-651) (ABIN7150963)

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-PIAS1 Antikörper

Bindungsspezifität: AA 422-651

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 SUMO-protein ligase PIAS1 protein (422-651AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIAS1

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Andere Bezeichnung: PIAS1

Hintergrund:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at\\\'Lys-65\\\' and \\\'Lys-160\\\') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Aliases: AR interacting protein antibody, DDXBP1 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 antibody, DEAD/H box binding protein 1 antibody, DEAD/H box-binding protein 1 antibody, E3 SUMO-protein ligase PIAS1 antibody, GBP antibody, Gu binding protein antibody, Gu-binding protein antibody, GU/RH-II antibody, Pias1 antibody, PIAS1_HUMAN antibody, Protein inhibitor of activated STAT protein 1 antibody, Protein inhibitor of activated STAT, 1 antibody, RNA helicase II binding protein antibody, RNA helicase II-binding protein antibody, Zinc finger, MIZ-type containing 3 antibody, ZMIZ3 antibody

UniProt: O75925

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C