DTNBP1 Antikörper (AA 258-351) (FITC)

Produktnummer ABIN7150912

Dieses Anti-DTNBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DTNBP1 in . Geeignet für Human.

Kurzübersicht für DTNBP1 Antikörper (AA 258-351) (FITC) (ABIN7150912)

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTNBP1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-DTNBP1 Antikörper (FITC)

Bindungsspezifität: AA 258-351

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Dysbindin protein (258-351AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DTNBP1

Target: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Andere Bezeichnung: DTNBP1

Hintergrund:

Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

Aliases: DTBP1_HUMAN antibody, DTNBP1 antibody, Dysbindin antibody, Dysbindin-1 antibody, Dystrobrevin binding protein 1 antibody, Dystrobrevin-binding protein 1 antibody, Hermansky Pudlak syndrome 7 protein antibody, Hermansky-Pudlak syndrome 7 protein antibody, HPS7 antibody, HPS7 protein antibody

UniProt: Q96EV8

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling