CLK2 Antikörper (AA 240-499)

Produktnummer ABIN7150731

Der Kaninchen-Polyklonal Anti-CLK2-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet zum Nachweis von CLK2 in Proben aus Human. }

Kurzübersicht für CLK2 Antikörper (AA 240-499) (ABIN7150731)

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CLK2 Antikörper

Bindungsspezifität: AA 240-499

Verwendungszweck: CLK2 Antibody

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CLK2

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Andere Bezeichnung: CLK2

Hintergrund:

Background: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Aliases: CDC like kinase 2 antibody, CDC-like kinase 2 antibody, CLK 2 antibody, CLK kinase antibody, CLK2 antibody, Clk2 Scamp3 antibody, CLK2_HUMAN antibody, Dual specificity protein kinase CLK2 antibody, hCLK 2 antibody, hCLK2 antibody, Tu52 antibody

UniProt: P49760

Pathways: Regulation of Carbohydrate Metabolic Process