IKZF1 Antikörper (AA 1-265) (HRP)

Produktnummer ABIN7150366

Dieses Anti-IKZF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IKZF1 in ELISA. Geeignet für Human.

Kurzübersicht für IKZF1 Antikörper (AA 1-265) (HRP) (ABIN7150366)

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKZF1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-IKZF1 Antikörper (HRP)

Bindungsspezifität: AA 1-265

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA-binding protein Ikaros protein (1-265AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu IKZF1

Target: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Andere Bezeichnung: IKZF1

Hintergrund:

Background: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

Aliases: CLL associated antigen KW 6 antibody, DNA-binding protein Ikaros antibody, hIk 1 antibody, Hs.54452 antibody, IK1 antibody, Ikaros (zinc finger protein) antibody, IKAROS antibody, IKAROS family zinc finger 1 (Ikaros) antibody, Ikaros family zinc finger protein 1 antibody, Ikzf1 antibody, IKZF1_HUMAN antibody, LYF1 antibody, Lymphoid transcription factor LyF-1 antibody, PRO0758 antibody, Zinc finger protein subfamily 1A 1 (Ikaros) antibody, Zinc finger protein subfamily 1A 1 antibody, Zinc finger protein, subfamily 1A, member 1 antibody, ZNFN1A1 antibody

UniProt: Q13422

Pathways: Production of Molecular Mediator of Immune Response