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DNA2 Antikörper (AA 1-300)

DNA2 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7150306
  • Target Alle DNA2 Antikörper anzeigen
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Bindungsspezifität
    • 4
    • 1
    • 1
    AA 1-300
    Reaktivität
    • 19
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DNA2 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 7
    • 5
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: IHC:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Andere Bezeichnung
    DNA2 (DNA2 Produkte)
    Synonyme
    DNA2L antikoerper, Dna2l antikoerper, E130315B21Rik antikoerper, PEOA6 antikoerper, hDNA2 antikoerper, XDna2 antikoerper, dna2-A antikoerper, DNA replication helicase/nuclease 2 antikoerper, DNA replication helicase/nuclease 2 S homeolog antikoerper, DNA2 antikoerper, Dna2 antikoerper, dna2.S antikoerper
    Hintergrund

    Background: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.

    Aliases: DNA replication ATP-dependent helicase-like homolog antibody, DNA replication helicase 2 homolog antibody, DNA replication helicase 2, yeast, homolog of antibody, DNA replication helicase 2-like antibody, DNA replication helicase/nuclease 2 antibody, DNA2 antibody, DNA2-like helicase antibody, DNA2L antibody, DNA2L_HUMAN antibody, HDNA2 antibody, KIAA0083 antibody, PEOA6 antibody, SCKL8 antibody

    UniProt
    P51530
    Pathways
    Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA
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