POLI Antikörper (AA 458-711)
Kurzübersicht für POLI Antikörper (AA 458-711) (ABIN7150251)
Target
Alle POLI Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 458-711
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human DNA polymerase iota protein (458-711AA)
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Isotyp
- IgG
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Applikationshinweise
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- POLI (Polymerase (DNA Directed) iota (POLI))
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Andere Bezeichnung
- POLI
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Hintergrund
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Background: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5\'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Aliases: DNA polymerase iota antibody, Eta 2 antibody, Eta2 antibody, POLI antibody, POLI_HUMAN antibody, Polymerase (DNA directed) iota antibody, RAD 30B antibody, RAD30 homolog B antibody, RAD30, S. cerevisiae, homolog of antibody, RAD30B antibody, RAD3OB antibody
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UniProt
- Q9UNA4
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Pathways
- DNA Reparatur
Target
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