DOCK1 Antikörper (AA 1676-1865)

Produktnummer ABIN7149579

Produktdetails anti-DOCK1 Antikörper

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Bindungsspezifität: AA 1676-1865

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Dedicator of cytokinesis protein 1 protein (1676-1865AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DOCK1

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Andere Bezeichnung: DOCK1 (DOCK1 Produkte)

Synonyme: DOCK180 antikoerper, ced5 antikoerper, 9130006G06Rik antikoerper, AI854900 antikoerper, D630004B07Rik antikoerper, RGD1566072 antikoerper, dedicator of cytokinesis 1 antikoerper, dedicator of cytokinesis protein 1 antikoerper, dedicator of cyto-kinesis 1 antikoerper, DOCK1 antikoerper, Dock1 antikoerper, dock1 antikoerper, CpipJ_CPIJ002759 antikoerper

Hintergrund:

Background: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).

Aliases: 180 kDa protein downstream of CRK antibody, Ced5 antibody, Dedicator of Cytokinesis 1 antibody, Dedicator of cytokinesis protein 1 antibody, DOCK 1 antibody, DOCK 180 antibody, DOCK1 antibody, DOCK1_HUMAN antibody, DOCK180 antibody

UniProt: Q14185

Pathways: Signaling of Hepatocyte Growth Factor Receptor