ATF6 Antikörper (AA 1-194)

Produktnummer ABIN7148805

Der Kaninchen Polyklonal Anti-ATF6-Antikörper wurde für IHC, ELISA und IF validiert. Er ist geeignet, ATF6 in Proben von Human zu detektieren.

Kurzübersicht für ATF6 Antikörper (AA 1-194) (ABIN7148805)

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-ATF6 Antikörper

Bindungsspezifität: AA 1-194

Kreuzreaktivität: Human

Aufreinigung: >95%, Antigen Affinity purified & Affinity purified

Immunogen: Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 alpha protein (1-194AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:100-1:500, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ATF6

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Andere Bezeichnung: ATF6

Hintergrund:

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5\'-CCAC[GA]-3\'half of the ER stress response element (ERSE) (5\'-CCAAT-N(9)-CCAC[GA]-3\') and of ERSE II (5\'-ATTGG-N-CCACG-3\'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Aliases: Activating transcription factor 6 alpha antibody, Activating transcription factor 6 antibody, ATF 6 antibody, ATF6 alpha antibody, ATF6 antibody, ATF6-alpha antibody, ATF6A antibody, ATF6A_HUMAN antibody, cAMP dependent transcription factor ATF 6 alpha antibody, cAMP-dependent transcription factor ATF-6 alpha antibody, Cyclic AMP dependent transcription factor ATF 6 alpha antibody, DKFZp686P2194 antibody, ESTM49 antibody, FLJ21663 antibody, Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody, Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response